Figure 5a–c highlights an enhanced production of different tumor-sustaining factors, such as IL-8, IL-6, and MMP-9, in dHL60 cells activated with A375 CSC–CM; on the other hand, no significant changes in the synthesis of TNF-α, a well-known N1 state marker, were observed (Figure 5d). This evidence concerns the gene CXCL8 and neoplasm.