Classically, they represent the first line of defense in the innate arm of the immune system; however, various pro-inflammatory cancer-derived cytokines, such as transforming growth factor-beta (TGF-β), interleukin 6 (IL-6), and interleukin 8 (IL-8), have been reported to drive neutrophil recruitment and polarization, promoting their switch from an anti-tumor (N1) to an immunosuppressive and tumor-sustaining phenotype (N2) [6,7]. The gene discussed is IL6; the disease is neoplasm.