Genes involved in histone modification (BAP1, 13%; SETD2, 11%; ASXL1, 4%), chromatin remodelling (SMARCA4, 4%), and DNA methylation (DNMT3A, 7%; TET2, 4%; WT1, 4%) were frequently mutated in thymic carcinomas, but not thymomas. The gene discussed is ASXL1; the disease is thymic carcinoma.