In hypoxic conditions, hypoxia-inducible factor 1α (HIF-1α) represses the expression of miR-34a in tumor protein 53 (TP53)-mutated CRC cells, which leads to hypoxia-induced EMT through activation of signal transducer and activator of transcription 3 (STAT3). The gene discussed is TP53; the disease is colorectal carcinoma.