Fusobacterium, and in particular F. nucleatum, attaches to and invades human cells via the FadA adhesin, activating β-catenin signaling, increasing expression of transcription factors LEF/TCF and NF-κB and cytokines IL-6, IL-8, and IL-18, thus being able to generate a pro-inflammatory microenvironment and promote growth of CRC cells [78]. This evidence concerns the gene HNF4A and colorectal carcinoma.