As a nucleoplasm-located DUB, USP28, ubiquitin-specific peptidase 28, is among the deubiquitinases that alter the stability and turnover of critical cancer oncoproteins such as cMYC involved in the proliferation and aggressiveness of colon and breast carcinoma and glioblastoma cells [77,78,79]. Here, USP28 is linked to glioblastoma.