Moreover, USP28, in addition to its role in tumor-promoting substrate stabilization qualifying as a proto-oncoprotein, it also controls the stability of several proteins involved in DNA damage response (CHEK2) [81], the metabolism (HIF1) [82], translation (JAK-STAT) [83], and the cell cycle (TP53) [84], all of which are relevant pathways in melanoma development and MAPKinh response. This evidence concerns the gene USP28 and melanoma.