USP22 controls cell growth and activation in different ways: it induces changes in gene promoter regions by removing ubiquitin moieties from histones H2A and H2B leading to transcription activation [71], and it induces cell cycle progression by stabilizing TRF1 [72], COX-2 [73], CCNB1 (Cyclin-B1) [74], CCND1 (Cyclin D1), NFAT, and SIRT1 [75], which regulate the genes involved in metabolism, cell cycle, invasion, and apoptosis, a pathway implicated in melanoma progression [76]. This evidence concerns the gene CCNB1 and melanoma.