ZUP1 and Machado-Joseph disease: Around 100 DUBs are encoded in the human genome and have been divided into six families based on sequence and structure, including UCH (ubiquitin C-terminal hydrolase), USP (ubiquitin-specific protease), OTU (ovarian tumor proteases), Josephin (Machado-Joseph disease, MJD), ZUP1 (zinc finger-containing ubiquitin peptidase), and the JAMMs (JAB1/MPN/Mov34 metalloenzyme) [36,37,38].