The single-cell transcriptome data revealed that TNBC tumor samples with high PANX1 expression had lower infiltration of B cells, CD4+ T cells, CD8+ T cells, myeloid cells, NK cells, and NK T cells and higher infiltration of cancer-associated fibroblasts (CAFs), plasma cells, and Tregs (Supplementary Figure S2E,F). Here, CD8A is linked to neoplasm.