PANX1 and melanoma: It was reported that PANX1 had certain effect on the prognosis and metastasis of various tumor, such as pro-carcinogenic effects in pancreatic adenocarcinoma [40], breast cancer [13,41], hepatocellular carcinoma [42], testicular carcinoma [43], melanoma [44], and anticarcinogenic effects in rhabdomyosarcoma [45].