Compared with normal tissues, we found that PANX1 was highly expressed in breast cancer (BRCA), colon adenocarcinoma (COAD), esophageal carcinoma (ESCA), head and neck squamous cell carcinoma (HNSC), kidney chromophobe (KICH), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), and stomach adenocarcinoma (STAD) based on the web tool TIMER (TCGA-BRCA data) (p < 0.001 was significant) (Figure 1A). This evidence concerns the gene PANX1 and colon adenocarcinoma.