NOTCH3 and ovarian serous carcinoma: Techniques like SNP array, karyotyping, and transcriptomics identified Notch3, a single-pass transmembrane receptor heterodimer, as altering (mostly as gene amplification and increase in mRNA copies) 21% of high grade serous ovarian carcinomas (HGSOC), while 61% of all patients have at least one alteration in the Notch3 pathway.