CHEK2 and breast carcinoma: Three of these variants were observed in known breast cancer susceptibility genes, one in ATM (c.1564_1565delGA, OR = 8.77 (CI 95% 1.11–69.29), p-value = 0.040), which is reported as pathogenic in the ClinVar database [30], and two in CHEK2 (c.1100delC, OR = 3.08 (CI 95% 2.01–4.3), p-value = 2.83 × 10−7; c.444 + 1G > A, OR = 8.12 (CI 95% 1.03–64.13), p-value = 0.047).