We found nominal evidence of association with breast cancer overall for LoF variants in three genes (ZFAND1, TMEM206/PACC1, and TYRO3), with ER-negative breast cancer in two genes, DNAH11 and PARP2, and with ER-positive disease in four genes LAMC3, MTMR11, EPN3, and SLC22A10. The gene discussed is PACC1; the disease is breast carcinoma.