For the remaining suspected susceptibility genes, including genes confirmed to be associated with breast cancer risk or predisposition to specific cancer syndromes, as studied by Lee et al. [46], Dorling et al. [18], and/or Hu et al. [27] (BARD1, CDH1, PTEN, RAD51C, RAD51D, STK11, TP53), the frequencies of LoF and rare missense variants were too low in our study to detect or support an association with breast cancer risk. This evidence concerns the gene PTEN and breast cancer.