CHEK2 and breast carcinoma: In the panel of 32 known or suspected breast cancer susceptibility genes, there was evidence of an association with overall breast cancer risk for rare missense variants in four genes: ATM (OR = 1.67 (CI 95% 1.32–2.10), p-value = 1.56 × 10−5); CHEK2 (OR = 1.95 (CI 95% 1.35–2.82), p-value = 3.43 × 10−4); TP53 (OR = 2.22 (CI 95% 1.26–3.93), p-value = 5.86 × 10−3) and MEN1 (OR = 5.93 (CI 95% 1.33–26.50), p-value = 0.020) (Figure 2 and Table S7).