LoF variants in three genes (ZFAND1, TYRO3, and TMEM206/PACC1) displayed modest evidence of an association with breast cancer risk overall (p-value < 0.05) (Figure 3 and Table 2), with effect sizes for ZFAND1 of 1.73 (CI 95% 1.12–2.68, p-value = 0.014), TYRO3 of 1.40 (CI 95% 1.06–1.83, p-value = 0.016), and TMEM206/PACC1 of 1.70 (CI 95% 1.11–2.62, p-value = 0.016). Here, PACC1 is linked to breast cancer.