CHEK2 and breast cancer: Significant associations for LoF variants with overall breast cancer risk were observed for CHEK2 (OR = 3.47 (CI 95% 2.33–5.15), p-value = 7.62 × 10−10); ATM (OR = 3.55 (CI 95% 2.16–5.82), p-value = 5.44 × 10−7); and PALB2 (OR = 3.95 (CI 95% 1.98–7.88), p-value = 9.68 × 10−5), while more modest evidence of overall risk association was observed for TP53 (OR = 10.16 (CI 95% 1.31–78.67, p-value = 0.026) (Figure 2 and Table 1).