ABCC2 and breast cancer: The combined analysis of LoF and rare missense variants (Table 2) identified a new association for ABCC2 (p-value = 0.038) with overall breast cancer, and also identified additional distinct associations for two genes for which evidence of associations had been observed in either separate LoF or missense variants analyses, namely, a modest association of SMARCA2 with overall breast cancer (OR = 2.43 (CI 95% 1.01–5.82), p-value = 0.046), and one for TMEM206/PACC1 with ER-negative breast cancer (OR = 2.26 (CI 95% 1.13–4.51), p-value = 0.021).