Tumor subtype analyses of LoF variants revealed evidence of association for ZFAND1, TYRO3, DNAH11, and PARP2 with ER-negative breast cancer, with ZFAND1 showing the strongest association (OR = 2.96 (CI 95% 1.59–5.50), p-value = 6.37 × 10−4). Here, ZFAND1 is linked to neoplasm.