For the remaining suspected susceptibility genes, including genes confirmed to be associated with breast cancer risk or predisposition to specific cancer syndromes, as studied by Lee et al. [46], Dorling et al. [18], and/or Hu et al. [27] (BARD1, CDH1, PTEN, RAD51C, RAD51D, STK11, TP53), the frequencies of LoF and rare missense variants were too low in our study to detect or support an association with breast cancer risk. The gene discussed is PTEN; the disease is breast carcinoma.