BARD1 and breast cancer: Among genes that were not associated with overall breast cancer risk, missense variants in BARD1 showed some evidence of association with ER-positive disease (OR = 2.14 (CI 95% 1.13–4.04), p-value = 0.020), while an association with ER-negative breast cancer was observed for missense variants in BRIP1 (OR = 3.78 (CI 95% 1.23–11.55), p-value = 0.020) (Figure 2, Table S7).