TNF and neoplasm: The Figure 2B shows the correlations between the two tumor groups and the immunity-related parameters: most of parameters were positively associated with the “CISH-up/PDL1-up” group, with OR superior to those observed in Figure 2A. Notably, the more discriminant odds ratio (OR) of the “CISH-up/PDL1-up” group was now obtained for IFNα, IFNγ and TNFα pathways, the three major cytokines responsible for cytotoxic function, the Th1 cell and the CD8 cell subsets.