Increased expression of syntenin-1 in tumor cells: The expression of syntenin-1, which interacts directly with ALIX (via three LYPXnL motifs located within ALIX’s conserved cytoplasmic domains), is upregulated in several cancer types, including breast cancer, lung cancer, and melanoma [261,262,263]. The gene discussed is PDCD6IP; the disease is neoplasm.