Moreover, Yang et al. demonstrated that hepatocarcinoma (HCC) cells with high metastatic potential are able to transfer exosomes containing miR-92a-3p to HCC cells with low metastatic potential, by promoting the EMT-mediated PEN/Akt pathway, as demonstrated by the increased expression of mesenchymal biomarkers (N-cadherin, β-catenin, Snail) and decreased expression of E-cadherin [275]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.