In terms of KEGG pathway analysis, in Figure 1F and Table 2, the NB group enriched unique pathways such as cytokine-cytokine receptor interaction, cell adhesion molecules (CAMs), the Jak-STAT signaling pathway, NF-kappa B signaling pathway, focal adhesion, the PI3K-Akt signaling pathway, pathways in cancer and the MAPK signaling pathway. The gene discussed is PIK3CA; the disease is neuroblastoma.