LPAR1 and neuroblastoma: The results of LPAR1 expression analysis at different stages (the International Neuroblastoma Staging System (INSS)) indicated that LPAR1 showed the lowest expression level in st4 NB tumors with metastasis, rather than st4s with limited metastasis, both of which expressed lower LPAR1 levels than st1, st2 and st3 NB tumors (Figure 3E).