In terms of KEGG pathway analysis, in Figure 1F and Table 2, the NB group enriched unique pathways such as cytokine-cytokine receptor interaction, cell adhesion molecules (CAMs), the Jak-STAT signaling pathway, NF-kappa B signaling pathway, focal adhesion, the PI3K-Akt signaling pathway, pathways in cancer and the MAPK signaling pathway. This evidence concerns the gene PIK3CA and cancer.