In this context, GPCR 16 has been shown to decrease adhesion and increase cellular proliferation in NSCLC in the presence of two novel oncogenic proteins, namely endothelial transcription factor 2 (E2F2) and EGF-like module-containing, mucin-like, hormone receptor-like 2 (EMR2). Here, ADGRE2 is linked to non-small cell lung carcinoma.