For instance, Mohamed et al. [45] reported that the PERK pathway is involved in the immunosuppressive function of MDSC, and Cubillos-Ruiz et al. [19] illustrated that IRE1α-XBP1 axis activation in DCs leads to antigen-presenting dysfunction and corrupted antitumor effects of T cells in ovarian cancer. The gene discussed is EIF2AK3; the disease is ovarian cancer.