ASNS and malignant colon neoplasm: Among the 14 genes, ASNS, known as asparagine synthetase, has been shown to promote colon cancer progression through increasing asparagine level [55]; EIF2AK4, a risk factor identified in our study, has been shown to be a promising target in CRC treatment [56]; and YOD1 was shown to participate in gallbladder cancer progression [57].