MCL1 and acute myeloid leukemia: AZD-5991 is a macrocyclic molecule with high selectivity and affinity for Mcl-1, due to the fact that it binds directly to Mcl-1; it induces rapid apoptosis in cancer cells, most notably MM and acute myeloid leukemia, via activation of the Bak-dependent mitochondrial apoptotic pathway [57].