Furthermore, only two procedures with IVD-CE validation and approved by the FDA for clinical use could be used until recently: the CELLSEARCH system (Menarini Silicon Biosystems, Huntingdon Valley, PA, USA) for the detection of circulating tumor cells (CTCs) in the case of breast, colon and prostate cancer; and the cobas® EGFR Mutation Test V2 system (Roche Diagnostics, Mannheim, Germany) for cell-free DNA (cfDNA) in lung cancer. The gene discussed is EGFR; the disease is neoplasm.