In another study, CAF has been shown to induce HIF-1α-dependent oxidative response, thereby increasing the expression of CXCR4 and interleukin-6 (IL-6) receptors in prostate cancer cells to promote epithelial-to-mesenchymal transition (EMT) and invasion of the tumor cells [70]. The gene discussed is HIF1A; the disease is prostate carcinoma.