It has been shown that hypoxia activates TGF-β signaling via HIF-1α to convert fibroblasts into myofibroblasts, which in turn induces C-X-C motif chemokine 13 (CXCL13) expression for B cell recruitment and metastatic progression of prostate cancer cells. The gene discussed is CXCL13; the disease is Familial prostate cancer.