ACTA1 and pulmonary fibrosis: Interestingly, Meflin+ fibroblasts have been found in the stroma of non-tumor fibrotic diseases, such as cardiac fibrosis, idiopathic pulmonary fibrosis, and kidney fibrosis, where they seem to be essential for tissue repair, but also play a role in suppressing fibrosis, unlike α-SMA+ myofibroblasts, which promote tissue fibrosis and stiffening [40,69,70].