Rs2157719 is also intronic to the non-coding RNA, CDKN2B antisense RNA 1 (CDKN2B-AS1), also known as ANRIL (Figure 3E), which is linked to the progression of diabetic nephropathy, one of the most common T2D complications [57]; however, the prominence of CDKN2B-AS1 in the literature to date is mostly due to its role in cancer, where it can enhance cell proliferation, cell cycle progression, and inhibit apoptosis and senescence. Here, CDKN2B is linked to diabetic kidney disease.