Individual mutational tumor load comparison between cfDNA and PBMCs shows significant differences in selected mutations (FLT3-ITD, KRAS, NPM1, DNMT3A), whereas in the rest of the analyzed mutations no significant difference in the tumor load was found (SF3B1, U2AF1, IDH1/2, JAK2, NRAS). This evidence concerns the gene NPM1 and neoplasm.