MUC16 and endometrial cancer: When we applied the individual decision thresholds derived from the main study cohort, urine CA125 predicted endometrial cancer with a sensitivity of 72% (95% CI 52,86) and specificity of 71% (95% CI 58,81), while urine HE4 predicted endometrial cancer with a sensitivity of 32% (95% CI 17.2, 51.6) and specificity of 88% (95% CI 77.5, 94.1).