MUC16 and endometrial cancer: The combined model of CA125 and endometrial thickness as continuous variables was the best-performing model, improving the specificity of endometrial thickness alone, and predicted endometrial cancer with an AUC of 0.97 (95% CI 0.93, 1.00, p < 0.001) (Figure 4), however, the incremental benefit accruing from urine CA125 was not statistically significant (p = 0.447).