Urine CA125 and HE4 predicted Type II endometrial cancers with AUC values of 0.81 (95% CI 0.64, 0.99, p = 0.003) and 0.72 (95% CI 0.54, 0.90, p = 0.04), respectively, and advanced-stage (FIGO stage III/IV) tumors with AUC values of 0.84 (95% CI 0.60, 1.00, p = 0.03) and 0.84 (95% CI 0.69, 0.99, p = 0.03), respectively (Figure S1). The gene discussed is MUC16; the disease is endometrial cancer.