Moreover, prolonged administration of AMD3100 to NOD/SCID mice engrafted with B-ALL cells significantly reduced the number of leukemic cells in peripheral blood (PB), spleen, liver and kidney, demonstrating that disruption of CXCL12 signaling inhibits the in vivo growth and dissemination of leukemic cells [75]. Here, CXCL12 is linked to acute lymphoblastic leukemia.