Mutations in several genes have been identified in CML patients, such as ASXL1, RUNX1, TET2, BCL6 Corepressor-Like 1 (BCORL1), GATA-binding factor 2 (GATA2), and others [81]. The gene discussed is RUNX1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.