Although little is known about survival conditions of DTCs in the BM, some DTCs were shown to have stem cell character with the ability of self-renewal [8,9] and we recently demonstrated that early staged diagnosed BC patients harboring DTCs expressing the chemokine receptor type 4 (CXCR4) and the transcription factor JUNB had a higher risk for relapse [10]. Here, CXCR4 is linked to breast cancer.