ERBB2 and breast carcinoma: After cooling to 35 °C (lower critical solution temperature (LCST)), the polymer entered into an extended state and released the HBP in aqueous media to enhance the AIE-based emission (from J-type nanoaggregates of BP and π–π stacking) for monitoring human epidermal growth factor receptor-2 (HER2) from the breast cancer cells inhibition.