PIK3C2A and acute kidney injury: Adverse effects of the prolonged use of daptomycin have been described and include the elevation of serum creatin phosphokinase (CPK), rash, eosinophilic pneumonia, or acute renal failure secondary to massive rhabdomyolysis [18], although there are some trials [19] in which doses of 6–8 mg/kg/day up to six weeks have been used for PJI in patients undergoing two-stage revisions, with great results in terms of efficacy and safety.