CXCL8 and gastric cancer: Recruitment of leukocytes in the gastric mucosa → the regulation of immune-inflammatory responses [38]Allele -251 of the IL-8 gene is associated with the host’s increased susceptibility to developing H. pylori infection [43]IL-8 251 AT gene polymorphism → a protective effect for acute chronic gastritis development in women and a risk factor in males [44]Xue et al → IL-8-251AA genotype is not associated with H. pylori infection, but it increases the risk of developing gastric cancer [45]