CXCL8 and gastric cancer: Moreover, these findings demonstrate that IL-1β acts synergistically, with IL-6 substantially augmenting the inflammatory responses triggered by H. pylori. Another important interrelation with a great impact on gastric carcinogenesis was identified between IL-1β 511 T and IL-8 251 T gene polymorphisms, which in the setting of increased virulence of H. pylori results in a higher risk of gastric cancer [44] (Table 1).