The studies specifically using GYY4137 also reported the sulfhydration of KEAP1, activation of NRF2, and induction of genes regulated by NRF2 in experimental models of diabetes-accelerated atherosclerosis, sepsis, HIV-1 latency, renal ischemia/reperfusion injury, and liver damage [32,38,39,40,48]. This evidence concerns the gene KEAP1 and diabetes mellitus.