EC-targeted Trx2+/+ mice show increased scavenging activity for H2O2 and O2•− [72], ApoE−/−/Trx2+/+ mice show improved EC function and reduced atherosclerosis [72] and mice with targeted cardiac Trx2−/− exhibit high oxidative status and vascular lesions [73,74] (Table 2). Here, APOE is linked to atherosclerosis.