The Met-Leu (M/L) 54 PON1 polymorphism is associated with reduced serum PON1 in DM subjects and correlates with increased ASCVD [87], the M/L55 and Gln-Arg (Q/R) 192 PON1 polymorphism is also associated with reduced serum PON1 activity and CAD [88,89] (Table 2). This evidence concerns the gene PON1 and coronary artery disorder.