CAT and atherosclerosis: In conclusion, genetically modified mice overexpressing Cat, Cat+SOD1 [60], PRDX4 [60], or Trx2 in ECs [72] and the deletion of scavenger systems such as the nuclear factor [erythroid-derived 2]-like 2 related factors 2 (Nrf-2) [115], GPX1 [116], SOD2, and PRDX1 and 2 [3] indicate a protective role in atherosclerosis.