CAT and aortic atherosclerosis: Mitochondrial oxidative stress appears to be reduced by Cat+/+ targeted to macrophages or myeloid cells in LDL−/− mice, with reduced aortic lesions [63,64], and ApoE−/−/Cat+/+ mice show reduced aortic atherosclerosis and 8-epi-PGF2α expression [60,61] (Table 2).