AKT1 and diabetes mellitus: In streptozotocin (STZ)-treated rats that develop DM, the supplementation of melatonin (20 mg/kg once daily (od) per os) for 8 weeks could recover Notch homolog-1 translocation associated/hairy and enhancers of split/protein kinase B (Notch1/Hes/Akt) signal in an I/R injury model and enhanced SOD in aortic VSMC [204] (Figure 4B).