CYBB and atherosclerosis: This defect is characterized by low atherosclerosis [29], circulating oxidized low-density lipoprotein (ox-LDL), urinary 8-epi-prostaglandin F2α (8-epi-PGF2α), a non-enzymatic product of lipid oxidation [29], low O2•− and high NO generation from platelets [43] (Table 1), suggesting a role for NOX2 in human atherogenesis.