Nrf2-knockout mice exhibited exacerbation of lipopolysaccharide (LPS)-induced sepsis-like inflammation, which was alleviated by treatment with NRF2 activators, such as CDDO-imidazolide [10] or a cysteine antioxidant N-acetylcysteine (NAC) [11]. This evidence concerns the gene NFE2L2 and Sepsis.