We have shown that, in an imiquimod (IMQ)-induced mouse model of psoriasis [102], Nrf2 deficiency exacerbated psoriatic skin inflammation and aberrant keratinization by upregulating mRNA expression levels of inflammatory cytokines (i.e., Il6, Tnf, Il23a, and Il17a) and protein expression level of phosphorylated STAT3, and downregulating protein expression levels of epidermal differentiation markers (i.e., K10, FLG, and LOR) [9]. Here, TNF is linked to psoriasis.