Interestingly, the latest study indicates that a JM17 concentration greater than or equal to 2 μM enhances accumulation of ROS, augments lipid peroxidation, and blocks GPx to suppress growth of temozolomide (TMZ)-sensitive glioblastoma through JM17-mediated androgen receptor ubiquitination; however, a decrease in cell viability occurred in normal astrocytes at more than a 10 μM dose of JM17 [27], which is similar to our finding in SK-N-SH neurons of WT and MJD78 where obvious cytotoxicity was observed at concentrations above 10  μM (Figure S3). Here, AR is linked to glioblastoma.