Overall, the transcription study of genes involved in lipid metabolism in liver, including PPARα, FAS, LPL, ATGL, HSL and CPT-1, indicated that taurine could ameliorate lipid metabolic disorders by inhibiting fat synthesis, facilitating fat hydrolysis and fatty oxidation via regulated PPARα action in oxidized oil-fed mice. This evidence concerns the gene PNPLA2 and Disorder of lipid metabolism.