VEGF, which is considered a potent inducer of angiogenesis secreted by neurons, glial, and vascular endothelial cells, has not only neurotrophic activity but also enhances neuronal survival and neurite outgrowth and leads to a functional improvement in the pathogenesis of stroke, Alzheimer’s disease, spinal cord injury, and motor neuron diseases [19]. Here, VEGFA is linked to motor neuron disorder.