RYR2 and cardiomyopathy: In HCM and cardiac muscle contraction pathways-related DEGs, the expression levels of Actb, Actg1, Des, Myl2/3, Cox4i1, Cox5a, Cox6a2, Cox7a1 and Tnnc1/i3/t2 were increased, while the expression levels of the genes (Dag1, Myh7, Itga2b, Itgb3, Prkab2, Ryr2, Cacna2d1 and Myl4) that promote cardiomyopathy were decreased in the GCN2iB group.