Even though embelin was found as an X-linked inhibitor of apoptosis protein (XIAP) inhibitor, it had no effect on XIAP in glioma cells, but instead reduced NF-κB activity by hindering the nuclear translocation of p65, as a result of decreasing phosphorylation and proteasomal degradation of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, and alpha (IκBα) in glioma cells. Here, NFKB1 is linked to central nervous system cancer.