Authors Yokoyama et al. (2014) investigated the skin hydration on atopic dermatitis in mice using C. olitorius leaf extract excluding high MW (COEW), and the results show a possible therapeutic benefit for atopic dermatitis due to decreased plasma immunoglobulin E (IgE) level as well as mast cell degranulation [145]. The gene discussed is IGHE; the disease is atopic eczema.