Mitochondrial dysfunction in cytokine storm-AKI has been associated with renal failure, which can lead to compensatory quality control mechanisms, as observed in biopsies from sepsis-associated AKI patients, in which genes involved in antioxidant defense, such as SIRT1, in mitochondrial biogenesis, as mitochondrial transcription factor A (TFAM) and PGC-1α and in mitophagy as PTEN-induced kinase 1 (PINK1) and Parkin RBR E3 ubiquitin-protein ligase (PARKIN), were downregulated [55]. The gene discussed is SIRT1; the disease is acute kidney injury.