Treatment with the AMPK activator AICAR (5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside) and the antioxidant ALCAR (acetyl-l-carnitine) increased PGC-1α expression and decreased the severity of cisplatin-AKI by reducing mitochondrial fragmentation, a mechanism that involves Sirt3 activation [43]. This evidence concerns the gene PPARGC1A and acute kidney injury.