The mtROS directly decrease the expression of the mitochondrial transcriptional factor TFAM in tubular cells undergoing hypoxia/reoxygenation and in murine IRI-AKI; in turn, decreased TFAM levels mediate mtROS-induced mitochondrial dysfunction and inflammation in tubular cells, although the effect of TFAM downregulation over cell death was not analyzed [15]. This evidence concerns the gene TFAM and acute kidney injury.