In addition, this phenolic acid can considerably reduce paw edema in a dose dependent manner but also limit inflammatory symptoms associated with ulcer by decreasing the levels of key pro-inflammatory cytokines, namely TNF-α, IL-1, IL-6 and IL-10, through modulation of NF-κB, MAPK and JAK-STAT signaling pathways [64]. The gene discussed is IL1B; the disease is ulcer disease.