As shown in Figure 6C,D and Figure S4C,D, expression levels of factors regulating mitochondrial biogenesis, including nuclear respiratory factor 1 (Nrf1), nuclear respiratory factor 2 (Nrf2) and mitochondrial transcription factor A (mtTFA) were severely decreased in both AD cortical tissue and N2a-SW cells. The gene discussed is NRF1; the disease is Alzheimer disease.