Another recent study revealed that the IRE-1α/XBP-1 axis is upregulated in B cells of SLE patients, and correlates with stearoyl-coenzyme A desaturase (Scd1 and Scd2) gene transcription and lipid accumulation in B cells of these patients, as compared to healthy controls [61]. The gene discussed is XBP1; the disease is systemic lupus erythematosus.