Given their conserved nature and abundance, particularly in stressed states, these molecules become favorable targets for regulatory T cells [96], and autoantibodies against molecular chaperones such as calnexin, GRP78 and GRP94 have been identified in SLE and RA, as well as numerous other rheumatic and inflammatory diseases [97,98]. The gene discussed is HSPA5; the disease is systemic lupus erythematosus.