Based on the previous observation that oral and nasal administration of specific peptides could induce Treg in animal models of autoimmune and inflammatory diseases [109], Shoda et al., 2015 studied two different HLA–DRB1*04:05-restricted epitopes of BiP (BiP 336–355 and BiP 456–475) and found they were differently recognized by effector and regulatory T cells [110]. This evidence concerns the gene HSPA5 and Autoimmunity.