The role of the PERK-eIF2α-ATF4 axis in SLE has been underexplored, although impaired signaling in the PERK axis has been demonstrated in PBMCs from SLE patients, where downregulation of PERK was found, particularly in patient with severe condition (SLEDAI ≥ 12) [14]. This evidence concerns the gene EIF2AK3 and systemic lupus erythematosus.