Finally, one study reported the use of HO-1 as a marker for disease progression in a patient with exacerbation of idiopathic pulmonary fibrosis (IPF) following SARS-CoV-2 infection and COVID-19, and they found that serum HO-1 which reflected M2 macrophage activation allowed monitoring of the disease progression [24]. This evidence concerns the gene HMOX1 and idiopathic pulmonary fibrosis.