Furthermore, whereas the evidence for a major role of KRIT1 in redox signaling and cell responses to oxidative stress and inflammation continues to grow [24,52], recent findings demonstrate that the consequences of KRIT1 LoF mutations may extend beyond CCM disease pathogenesis, also being implicated in atherosclerosis [53] and intestinal barrier dysfunction [54]. The gene discussed is KRIT1; the disease is atherosclerosis.