The NGS data analysis was performed in two steps: initially we considered the three known CCM genes, namely KRIT1 (CCM1), CCM2 and PDCD10 (CCM3), and subsequently extended the analysis to NGS panels, including the “Cerebro” panel composed of 23 genes associated with cerebrovascular diseases (Table 1). The gene discussed is KRIT1; the disease is cerebrovascular disorder.