The curcuminoids also mitigate iNOS, COX-2, TGF-β1/2, matrix metalloproteinase-9 (MMP-9), and brain-derived neurotrophic factor (BDNF) expression [92], attenuate α-synuclein aggregation [93], and generally, lessen the severity of the symptoms of neurodegenerative diseases [94] (Table 2). Here, MMP9 is linked to neurodegenerative disease.