The gingerols modulate various signaling pathways related to cancer, such as NF-κB, signal transducer and activator of transcription 3 (STAT3), MAPK, activator protein-1 (AP-1), β-catenin, proinflammatory mediators (tumor necrosis factor-α and COX-2), and growth factor receptors (epidermal growth factor receptor and vascular endothelial growth factor receptor) [98]. This evidence concerns the gene STAT3 and cancer.