Resveratrol, quercetin, curcumin, and compounds derived from plants including Punica granatum, Cichorium intybus, Carthamus tinctorius (Honghua)and Salvia miltiorrhiza (Danshen) could potentially prevent various diseases such as CVD, atherosclerosis, obesity, DM, hepatic disorders, and inflammatory diseases via affecting the PON1 signalling pathway [16]. The gene discussed is PON1; the disease is obesity due to melanocortin 4 receptor deficiency.