Cheng et al. reported that 50% ethanol extract of Graptopetalum paraguayense increased PON1 gene expression by protein kinase B/nuclear factor kappa-light-chain-enhancer of activated B cells (AKT/NF-κB)-dependent signalling pathway in a human liver cancer cell line (HepG2 cells) model (Table 1) (Figure 2) [19]. Here, AKT1 is linked to liver cancer.