In particular, evidence for the role of SIRT1 in restoring redox balance in psoriasis was obtained from an in vitro study of psoriatic fibroblasts in which the levels of 8-iso-PGF2α and intracellular ROS were significantly reduced after the addition of SRT1720, a selective activator of SIRT1 [113]. Here, SIRT1 is linked to psoriasis.