Regular exercise can improve NAFLD by diverse mechanisms such as decreasing intrahepatic fat content, producing hepato-protective autophagy, rising β-oxidation of fatty acids, overexpressing peroxisome proliferator-activated receptor-γ (PPAR-γ), rising insulin sensitivity, and attenuating hepatocyte apoptosis [28]. The gene discussed is INS; the disease is metabolic dysfunction-associated steatotic liver disease.