SLC23A2 and cancer: Uptake of vitamin C through SVCT2 has been shown to be induced by phosphorylation of the C-terminus of SVCT2 by JAK2 [166], therefore suggesting a localized additive effect between morphine and vitamin C; both compounds have also been shown to cause downstream STAT2 phosphorylation [165,166] resulting in upregulation of Nanog, a transcription factor noted in pluripotency and cancer.