SELENOP and obesity due to melanocortin 4 receptor deficiency: For obesity, the ELISA found no significance (SMD = 0.38, 95% CI: −0.02 to 0.77, n = 5), but the SPIA indicated higher SELENOP levels in patients than in the controls (SMD = 22.96, 95% CI: 15.80 to 30.13, n = 1) (Supplementary Figure S8).