Oltipraz (29) also hinders fat-induced insulin resistance and obesity via the upregulation of Nrf2 in C57BL/6J mice [144] and prevents high glucose-induced apoptosis and oxidative stress via activation of the Nrf2/NQO1 pathway in RSC96 cells [145]. The gene discussed is NFE2L2; the disease is obesity due to melanocortin 4 receptor deficiency.