FGF21 and preeclampsia: Moreover, the AUC ROC for predicting adverse maternal outcome of mild preeclampsia from serum FGF-21 levels was determined in the first (0.681 (95% confidence interval 0.537–0.826)) which was slightly better for prediction than during the second (0.644 (95% confidence interval 0.501–0.788)) and third (0.680 (95% confidence interval 0.523–0.836)) trimesters of pregnancy.