Therefore, the cut-off points in the levels of FGF-21 obtained through the different ROC curves in each trimester of pregnancy could contribute to the risk prediction of preeclampsia and further studies are needed to confirm a relationship between FGF-1 and Log (sFlt-1)/Log (PlGF) ratio and the outcome of preeclampsia [62]. The gene discussed is FGF21; the disease is preeclampsia.