The area under the receiver operating characteristic curve (AUC ROC) for predicting the development of the adverse maternal outcome of mild preeclampsia (dependent variable) from serum levels of FGF-21 levels (independent variable) was determined in the 1st (0.681 (95% confidence interval 0.537–0.826)), 2nd (0.644 (95% confidence interval 0.501–0.788)) and 3rd (0.680 (95% confidence interval 0.523–0.836)) trimesters of pregnancy (Figure 2a–c, respectively). This evidence concerns the gene FGF21 and preeclampsia.