Xi et al. found that LGI1 promoted oligodendrocyte development and myelination in the brain [55], and Fukata et al. found that the LGI1-ADAM22 protein complex is important for the formation of synaptic transmission in the brain, and the loss of LGI1 and ADAM22 led to epilepsy [36]. The gene discussed is LGI1; the disease is epilepsy.